Description
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 5
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-GIPC1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein GIPC1 also known as GAIP-interacting protein C terminus 1 weighs approximately 36 kDa. It functions mechanically as an adaptor protein binding to PDZ domains. Expressed widely throughout tissues GIPC1 shows high expression in the brain and heart. Acting at the cellular level it plays vital roles in receptor sorting and signal transduction through interactions with various cell surface proteins.
Biological function summary
The function of GIPC1 extends to endocytosis and cell signaling. It often forms part of protein complexes that facilitate intracellular trafficking. By interacting with membrane receptors like integrins and receptor tyrosine kinases GIPC1 aids in cell communication and adhesion processes. Its presence impacts the development and maintenance of cellular structures due to these complex formations.
Pathways
GIPC1 participates significantly in both the Wnt signaling and Ras signaling pathways. It associates with Dishevelled proteins in the Wnt pathway contributing to modulation of cell fate and proliferation. Additionally it connects to Ras-related signaling where it interacts with receptors such as the insulin-like growth factor receptor (IGF1R) thereby mediating downstream signaling effects important for cell growth and differentiation.
GIPC1 presents connections to cancer and diabetic retinopathy. In cancer aberrant GIPC1 expression influences tumor progression and metastasis by interacting with proteins like Ras and IGF1R affecting cellular proliferation and survival mechanisms. For diabetic retinopathy GIPC1 modulates angiogenic signals potentially through its partnerships with vascular endothelial growth factor receptor (VEGFR) pathways which leads to pathological neovascularization associated with vision impairment.
