Description
Key facts
Cell type:A549,
Species or organism:Human,
Tissue:Lung,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon 3 and 4 bp deletion in exon 3,
Disease:Carcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-BATF2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARI also known as suppressor of AP-1 regulates apoptosis and inflammation in cells. It is a protein with a molecular mass of around 64 kDa. SARI is mainly expressed in immune cells including macrophages and dendritic cells and also found in epithelial tissues. The protein acts mainly in the cytoplasm where it interacts with other molecules to carry out its functions.
Biological function summary
SARI modulates transcription processes involved in immune responses. It forms part of a regulatory complex that includes other proteins like TRAF3 and TBK1 to influence NF-κB signaling pathways. Through this complex SARI can suppress certain transcription factors thereby regulating gene expression linked to inflammation. This regulation helps maintain balanced immune responses ensuring cells do not overreact to stimuli.
Pathways
SARI interacts with the tumor necrosis factor (TNF) and toll-like receptor (TLR) signaling pathways. In these pathways SARI influences how cells respond to cytokines and infectious agents. It achieves this by interacting with key pathway proteins such as TRAF3 and RIPK1. These interactions allow SARI to mediate the downstream effects ultimately affecting cell survival and immune reactions.
SARI has roles in inflammatory diseases and cancer. In inflammatory diseases such as rheumatoid arthritis SARI influences the activity of inflammation-related proteins like NF-κB which can exacerbate or alleviate symptoms. In cancer SARI has been implicated in regulating tumor growth and metastasis interacting with other cancer-related proteins such as STAT3. These connections make SARI a potential therapeutic target in managing these conditions.
