Description
Key facts
CAS number:935666-88-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:348.76 Da,
Molecular formula:C14H14ClFN8,
PubChem:16659841,
Nature:Synthetic,
Solubility:?93.8 mg/mL in DMSO?4.57 mg/mL in EtOH with ultrasonic and warmingInsoluble in H2O,
Biochemical name:Azd-1480,
Biological description:Novel, potent and selective small-molecule JAK2 inhibitor (IC50 < 3 nM). It can effectively inhibit tumor angiogenesis and metastasis mediated by STAT3 in stromal cells as well as tumor cells. Also demonstrates >50-fold selectivity for JAK2 over JAK3.,
Canonical smiles:CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F,
Isomeric smiles:CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F,
InChi:InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1,
InChiKey:PDOQBOJDRPLBQU-QMMMGPOBSA-N,
IUPAC Name:5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
