Key facts
CAS number:467214-21-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:653.2 Da,
Molecular formula:C32H49ClN4O8,
PubChem:9852573,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM,
Biochemical name:Alvespimycin hydrochloride,
Biological description:A potent Hsp90 inhibitor (IC50 = 62 nM), can bind to the ATP-binding motif and inhibit the protein chaperoning activity.,
Canonical smiles:CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl,
Isomeric smiles:C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC.Cl,
InChi:InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1,
InChiKey:DFSYBWLNYPEFJK-IHLRWNDRSA-N,
IUPAC Name:[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride
Product details:
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
