Description
Key facts
CAS number:841258-76-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:332.4 Da,
Molecular formula:C20H20N4O,
PubChem:11427553,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone,
Biological description:Multi targeted inhibitor of FLT3 ( with an IC50 of 6.6nM), ABL, ABL-T315I, and Aurora kinase. Tumor growth inhibition in FLT3-mutated xenograft model in vitro. Shows a potent and significant antitumor effect in a dose-dependent manner in MOLM-13 tumour xenograft model in vivo.,
Canonical smiles:C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43,
Isomeric smiles:C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43,
InChi:InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+,
InChiKey:YYLKKYCXAOBSRM-JXMROGBWSA-N,
IUPAC Name:[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
