Key facts
CAS number:1191237-69-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:291.26 Da,
Molecular formula:C12H13N5O4,
PubChem:44468216,
Nature:Synthetic,
Solubility:~10 mg/ml in DMSO~10 mg/ml in DMF,
Biochemical name:(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile,
Biological description:The predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays against HCV, YFV, DENV-2, Influenza A, Parainfluenza 3 and SARS-CoV viruses with EC₅₀ values ranging from 1.7 μM-27.9 μM. It inhibits SARS-CoV and MERS-CoV infected human airway epithelial cell cultures with EC50 values of 0.18 μM and 0.86 μM respectively. GS-441524 is suggested for the treatment of COVID-19 due to lower toxicity and simpler synthesis when compared to remdesivir.,
Canonical smiles:C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N,
Isomeric smiles:C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N,
InChi:InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1,
InChiKey:BRDWIEOJOWJCLU-LTGWCKQJSA-N,
IUPAC Name:(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B3076 GS-441524. B3076-25 is the same size as the 5 mg size of ab286933.
Store in the dark. Product is light sensitive. Protect from air. Store under desiccating conditions.
Properties and Storage Information:
Shipped at conditions-Ambient - Cannot Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
