Description
Key facts
Cell type:U-87 MG,
Species or organism:Human,
Tissue:Brain,
Form:LiquidSee storage information,
Knockout validation:Next Generation Sequencing,
Disease:Glioblastoma
Product details:
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-ELAVL3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HuC also known as ELAVL3 is a neuronal-specific RNA-binding protein part of the ELAV (embryonic lethal abnormal vision) family. It plays a mechanical role in the stabilization and transport of mRNA. HuC has a mass of approximately 36 kDa. It is expressed predominantly in neuronal tissues particularly within the brain where it engages in critical functions related to neural RNA metabolism.
Biological function summary
HuC significantly influences neuronal differentiation and development. It participates in controlling the stability and translation of mRNA transcripts in neurons. HuC often functions as part of larger RNA-protein complexes impacting the post-transcriptional modification of target RNAs. Through its ability to bind mRNA HuC promotes the expression of proteins essential for neuron function affecting how neurons develop and maintain their activity.
Pathways
HuC integrates into the post-transcriptional regulatory networks in neurons. It influences the MAPK signaling pathway which is important for cell proliferation and survival. Within these pathways HuC interacts with proteins such as HuD another member of the ELAV family to ensure proper mRNA processing and translational control. These interactions are vital for maintaining neuronal integrity and response to external stimuli.
HuC has connections to neurodegenerative conditions such as Alzheimer's disease and certain types of cancer involving neuronal tissue. The dysfunction or aberrant expression of HuC disrupts normal neuronal function contributing to disease progression. In these contexts HuC often interacts with the Tau protein in Alzheimer's suggesting its involvement in the pathological pathways leading to cognitive decline. Additionally dysregulated interaction with other RNA-binding proteins like HuR might exacerbate disease states by altering the stability of RNA transcripts.
