Biolegend, 136407, Alexa Fluor® 488 anti-mouse CD309 (VEGFR2, Flk-1) Antibody
25microg
Catalog Number: 136407
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| Verified Reactivity | Mouse |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Murine Flk1 fused to hIgG Fc |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Blue Laser (488 nm) |
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| Application Notes |
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| Avas12 recognizes a different epitope than clone 89B3A5. Additional reported applications (for the relevant formats) include: Western blotting1 and immunohistochemical staining of paraformaldehyde-fixed frozen sections2. |
| Application References(PubMed link indicates BioLegend citation) | Kataoka H, et al. 1997. Dev. Growth Differ. 39:729. (WB) Ishitobi H, et al. 2010. Exp. Anim. 59:615. (IHC-F) |
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| Product Citations | Albiero M, et al. 2014. Diabetes. 63:1353. PubMed |
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| RRID | AB_2044064 (BioLegend Cat. No. 136407) AB_2044065 (BioLegend Cat. No. 136408) |
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| Structure | A receptor protein tyrosine kinase closely related to CD117 (c-kit) and CD140a (PDGF receptor α chain) of the immunoglobulin superfamily |
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| Distribution | Expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle |
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| Function | Plays an important role in the development of vascular endothelial cells, hematopoietic cells, and vascular permeability |
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| Ligand/Receptor | Vascular endothelial growth factor (VEGF) |
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| Biology Area | Angiogenesis, Cell Biology, Immunology |
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| Molecular Family | Adhesion Molecules, CD Molecules, Cytokine/Chemokine Receptors |
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| Antigen References | 1. Kaburn N, et al. 1997. Development. 124:2039 2. Patterson C, et al. 1995. J. Bio. Chem. 270:23111 3. Nishikawa SI, et al. 1998. Immunity 8 (6):761 4. Shalaby F, et al. 1997. Cell. 89 (6):981 |
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| Gene ID | 16542 |
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| UniProt | View information about CD309 on UniProt.org |
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| Clone | Avas12 |
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| Regulatory Status | RUO |
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| Other Names | Fetal liver kinase 1 (Flk-1), VEGF receptor-2, VEGF-R2, Ly-73, KDR |
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| Isotype | Rat IgG2a, κ |
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