Biolegend, 155523, Alexa Fluor® 488 anti-mouse CD170 (Siglec-F) Antibody
25microg
Catalog Number: 155523
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| Verified Reactivity | Mouse |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | 0.5 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Blue Laser (488 nm) |
| Product Citations | Hu X, et al. 2022. MedComm (2020). e193:3. PubMed Li F, et al. 2024. MBio. e0075624:15. PubMed Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed |
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| RRID | AB_2890713 (BioLegend Cat. No. 155523) AB_2890713 (BioLegend Cat. No. 155524) |
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| Structure | Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain |
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| Distribution | Eosinophils, alveolar macrophages, intestinal microfold (M) cells |
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| Function | Induces apoptosis in eosinophils |
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| Ligand/Receptor | [alpha]-2,3-linked sialic acid |
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| Cell Type | Eosinophils, Macrophages |
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| Biology Area | Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity |
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| Molecular Family | CD Molecules, Siglec Molecules |
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| Antigen References | Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1. Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329. Suzukawa M, et al. 2013. J. Immunol. 190:5939. Patnode ML, et al. 2013. J. Biol. Chem. 288:26533. |
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| Gene ID | 233186 |
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| UniProt | View information about CD170 on UniProt.org |
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| Clone | S17007L |
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| Regulatory Status | RUO |
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| Other Names | Siglec-5 |
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| Isotype | Rat IgG2a, κ |
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