Biolegend, 306027, Purified anti-human CD123 (Maxpar® Ready) Antibody
100microg
Catalog Number: 306027
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| Verified Reactivity | Human |
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| Reported Reactivity | Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human IL-3Rα transfected COS cells. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 1.0 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. |
| Application | FC - Quality tested CyTOF® - Verified |
| Recommended Usage | This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies. |
| Application Notes | Clone 6H6 does not inhibit IL-3 binding to low- or high-affinity IL-3Rs. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, and immunohistochemical staining of acetone-fixed frozen sections2 and also paraformaldehyde fixed paraffin embedded tissue7. |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Additional Product Notes | Maxpar® is a registered trademark of Standard BioTools Inc. |
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| Application References(PubMed link indicates BioLegend citation) | Sun Q, et al. 1996. Blood 87:83. (IP, WB) Herling M, et al. 2003. Blood 101:5007. (IHC) Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed Martin-Gayo E, et al. 2010. Blood 115:5366. PubMed Chen SC, et al. 2010. Arch Dermatol Res. 302:113. PubMed Liu Y, et al. 2012. Food Chem Toxicol. 50:1920. PubMed Peduzzi E, et al. 2007. J. Invest. Dermatol. 127:638. (IHC) |
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| Product Citations | Gañán-Gómez I, et al. 2022. Nat Med. . PubMed Jordan S, et al. 2020. Cell. 178(5):1102-1114.e17.. PubMed |
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| RRID | AB_2562823 (BioLegend Cat. No. 306027) |
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| Structure | Ig superfamily, type I transmembrane glycoprotein, associates with CDw131, 70 kD |
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| Distribution | Myeloid precursors, basophils, mast cells, macrophages, dendritic cells, megakaryocytes, subset of lymphocytes |
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| Function | Hematopoietic cell proliferation, differentiation |
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| Ligand/Receptor | IL-3 |
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| Cell Type | Basophils, Dendritic cells, Hematopoietic stem and progenitors, Lymphocytes, Macrophages, Mast cells, Megakaryocytes |
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| Biology Area | Immunology |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors |
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| Antigen References | 1. Miyajima A, et al. 1993. Blood 82:1960. |
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| Gene ID | 3563 |
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| UniProt | View information about CD123 on UniProt.org |
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| Clone | 6H6 |
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| Regulatory Status | RUO |
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| Other Names | IL-3Rα, IL-3 Receptor alpha |
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| Isotype | Mouse IgG1, κ |
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