Biolegend, 310207, Alexa Fluor® 594 anti-human CD45RB Antibody
25microg
Catalog Number: 310207
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| Verified Reactivity | Human |
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| Reported Reactivity | African Green, Baboon, Cynomolgus, Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human thymocytes and T lymphocytes |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
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| Application Notes | The MEM-55 antibody is specific for a glycosylated-CD45RB epitope that is highly expressed on memory B cells and plasmablasts but not on naïve B cells. Additional reported applications (for the relevant formats) include: immunoprecipitation, Western blotting, and immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections. |
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| Application References(PubMed link indicates BioLegend citation) | Horejsi V, et al. 1988. Folia Biol. 34:23. Bazil V, et al. 1989. Immunogenetics 29:202. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. Koethe S, et al. 2011. J. Leukoc. Biol. 90:5. |
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| RRID | AB_2734281 (BioLegend Cat. No. 310207) AB_2734282 (BioLegend Cat. No. 310208) |
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| Structure | Tyrosine phosphatases, type I transmembrane, 180-240 kD (exon 5 splicing of CD45 gene) |
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| Distribution | Thymocytes, T cell subset, B cells, monocytes/macrophages, granulocytes, dendritic cells |
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| Function | Enhances TCR and BCR signaling |
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| Ligand/Receptor | Galectin-1, CD2, CD3, CD4 |
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| Cell Type | B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, T cells, Thymocytes, Tregs |
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| Biology Area | Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | CD Molecules |
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| Antigen References | 1. Thomas M. 1989. Annu. Rev. Immunol. 7:339. 2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85. |
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| Gene ID | 5788 |
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| UniProt | View information about CD45RB on UniProt.org |
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| Clone | MEM-55 |
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| Regulatory Status | RUO |
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| Workshop | V CD45.08 |
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| Other Names | CD45RB |
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| Isotype | Mouse IgG2b, κ |
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