Biolegend, 313712, Alexa Fluor® 647 anti-human CD195 (CCR5) Antibody
100tests
Catalog Number: 313712
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | CHO cells transfected with human CCR5 |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Red Laser (633 nm) |
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| Application Notes | Additional reported applications (for the relevant formats) include: immunofluorescence microscopy1Clone HEK/1/85a and clone HEK/1/85a/7a are the same. |
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| Application References(PubMed link indicates BioLegend citation) | Mueller A, et al. 2002. Blood 99:785. Al-Odi E, et al. 2012. PLoS One. 7:e42217. PubMed Osman A, et al. 2014. J Immunol. 192:5083. PubMed Liu S, et al. 2014. Virus Res. 192:92. PubMed |
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| Product Citations | Park A, et al. 2016. Mol Ther Methods Clin Dev. 3:16057. PubMed Bergamaschi L, et al. 2021. Immunity. 54(6):1257-1275.e8. PubMed Piryani SO, et al. 2019. Stem Cell Reports. 13:76. PubMed Mandl M, et al. 2014. PLoS One. 9:112140. PubMed Fujigaki J, et al. 2015. PLoS One. 10: 0132521. PubMed Achour L, et al. 2008. Blood. 101182. PubMed Tadagaki K, et al. 2012. Blood. 119:4908. PubMed Maas RR, et al. 2021. Nat Protoc. 16:4692. PubMed |
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| RRID | AB_528759 (BioLegend Cat. No. 313711) AB_528760 (BioLegend Cat. No. 313712) |
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| Structure | G-coupled receptor family 1, membrane protein, 45 kD |
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| Distribution | Subset of T cells, monocytes |
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| Function | Binds C-C chemokines and transduces an intracellular signal thought to result in proliferation and differentiation. Acts as a co-receptor with CD4 for HIV-1 |
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| Ligand/Receptor | MIP-1α, MIP-1ß, RANTES |
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| Cell Type | Dendritic cells, Monocytes, T cells |
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| Biology Area | Immunology |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors, GPCR |
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| Antigen References | 1. Samson M, et al. 1996. Biochemistry 35:3362. 2. Raport CJ, et al. 1996. J. Biol. Chem. 271:17161. 3. Combadiere C, et al. 1996. J. Leukoc. Biol. 60:147. 4. Deng H, et al. 1996. Nature 381:661. 5. Lai J, et al. 2003. CVI. 10:1123. 6. Mañes S, et al. 2003. J. Exp. Med. 198:1381. 7. Vaday GG, et al. 2006. Prostate 66:124. |
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| Gene ID | 1234 |
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| UniProt | View information about CD195 on UniProt.org |
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| Clone | HEK/1/85a |
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| Regulatory Status | RUO |
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| Other Names | CCR5, C-C chemokine receptor type 5, HIV-1 fusion co-receptor |
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| Isotype | Rat IgG2a, κ |
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