Biolegend, 323210, Alexa Fluor® 488 anti-human CD105 Antibody
100tests
Catalog Number: 323210
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | L-cells transfected with human CD105 |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Blue Laser (488 nm) |
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| Application References(PubMed link indicates BioLegend citation) | Bühring HJ, et al. 1991. Leukemia 5:841. Vogel W, et al. 2002. Haematologica 88:126. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed HonMou O, et al. 2011. Brain. 134:1790. PubMed Herrera MB, et al. 2013. Hepatology. 57:311. PubMed Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed |
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| Product Citations | Donaubauer AJ, et al. 2018. Methods Mol Biol. 189:1904. PubMed Hopf A, et al. 2022. Bioengineering (Basel). 9:. PubMed Ji S, et al. 2021. Clin Sci (Lond). 135:1127. PubMed Cheng E, et al. 2009. Blood. 113:2826. PubMed Marolt D, et al. 2012. Proc Natl Acad Sci U S A. 109:8705. PubMed |
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| RRID | AB_755961 (BioLegend Cat. No. 323209) AB_2277939 (BioLegend Cat. No. 323210) |
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| Structure | Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD |
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| Distribution | Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells |
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| Function | Modulates cellular response to TGF-ß, involved in vascular development and remodelling |
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| Ligand/Receptor | TGF-ß1, TGF-ß3 |
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| Cell Type | Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes |
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| Biology Area | Angiogenesis, Cell Biology, Immunology, Stem Cells |
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| Molecular Family | Adhesion Molecules, CD Molecules |
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| Antigen References | 1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York. 2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195. |
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| Gene ID | 2022 |
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| UniProt | View information about CD105 on UniProt.org |
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| Clone | 43A3 |
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| Regulatory Status | RUO |
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| Other Names | Endoglin |
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| Isotype | Mouse IgG1, κ |
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