Biolegend, 331910, Alexa Fluor® 647 anti-human CD335 (NKp46) Antibody
100tests
Catalog Number: 331910
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | NKp46-Fc fusion protein |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Red Laser (633 nm) |
| Application Notes |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
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| Clone 9E2 has been shown to block NK activation through NKp46.6 |
| Application References(PubMed link indicates BioLegend citation) | Nakajima H, et al. 2000. Eur. J. Immunol. 30:3309. Kalberer CP, et al. 2003. Blood 102:127. Chen Y, et al. 2007. J. Immunol. 179:2766. Jarahian M, et al. 2009. J. Virol. 83:8108. PubMed Correia DV, et al. 2011. Blood 118:992. (FC) PubMed Achdout H. et al. 2010. J. Virol. 84:3993. |
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| Product Citations | Pérez-Quintero L, et al. 2014. J Exp Med. 211:727. PubMed Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed El Costa H, et al. 2021. PLoS Pathog. 17:e1009367. PubMed Correia DV, et al. 2011. Blood. 118:992. PubMed Pahl JHW, et al. 2018. Cancer Immunol Res. 0.609027778. PubMed |
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| RRID | AB_1027674 (BioLegend Cat. No. 331909) AB_2266918 (BioLegend Cat. No. 331910) |
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| Structure | Type I membrane glycoprotein (46 kD) |
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| Distribution | Expressed on resting and activated NK cells |
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| Cell Type | NK cells |
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| Biology Area | Immunology, Innate Immunity |
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| Molecular Family | CD Molecules |
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| Antigen References | 1. Mandelboim O and Porgador A. 2001. Int. J. Biochem. Cell Biol. 33:1147. 2. Nakajima H, et al. 2000. Eur. J. Immunol. 30:3309. 3. Sivori S. 1999. Eur. J. Immunol. 29:1656. |
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| Gene ID | 9437 |
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| UniProt | View information about CD335 on UniProt.org |
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| Clone | 9E2 |
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| Regulatory Status | RUO |
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| Other Names | NKp46, NCR1 |
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| Isotype | Mouse IgG1, κ |
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