Biolegend, 334639, Alexa Fluor® 488 anti-human FcεRIα Antibody
25tests
Catalog Number: 334639
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| Verified Reactivity | Human |
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| Reported Reactivity | Baboon, Cynomolgus, Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Blue Laser (488 nm) |
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| Application Notes | Clone AER-37 (CRA-1) has been reported to bind the receptor even in the presence of IgE.4 |
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| Application References(PubMed link indicates BioLegend citation) | Yamaguchi M, et al. 1999. J. Immunol. 162:5455. Suzukawa M, et al. 2005. Int. Immunol. 17:1249. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed Yamaguchi M, et al. 1999. J. Immunol. 162:5455. |
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| Product Citations | Liu C, et al. 2021. Cell Res. 31:1106. PubMed Camiolo MJ, et al. 2021. Cell Reports. 35(2):108974. PubMed |
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| RRID | AB_2721289 (BioLegend Cat. No. 334639) AB_2721290 (BioLegend Cat. No. 334640) |
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| Structure | Ig superfamily, 50 kD |
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| Distribution | Mast cells, basophils, cutaneuos Langerhans cells, dendritic cells, and monocytes from the patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils from hypereosinophilic syndrome, neutrophils from allergic asthmatic patients |
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| Function | Bind IgE, trigger IgE-mediated allergic response |
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| Ligand/Receptor | IgE |
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| Cell Type | Basophils, Dendritic cells, Eosinophils, Langerhans cells, Mast cells, Monocytes, Neutrophils |
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| Biology Area | Immunology |
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| Molecular Family | Fc Receptors |
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| Antigen References | 1. Riske F, et al. 1991. J. Biol. Chem. 266:11245 2. Gounni AS, et al. 2001. FASEB J. 15:940. 3. Maurer D, et al. 1996. J. Immunol. 157:607 4. Maurer d, et al. 1994. J. Exp. Med. 179:745 5. Campbell AM, et al. 1998. Am. J. Respir. Cell Mol. Biol. 19:92. |
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| Gene ID | 2205 |
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| UniProt | View information about FcepsilonRIalpha on UniProt.org |
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| Clone | AER-37 (CRA-1) |
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| Regulatory Status | RUO |
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| Other Names | FceRIa, FceRI-a, FceRI-alpha, FceRI alpha, high affinity IgE receptor |
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| Isotype | Mouse IgG2b, κ |
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