Biolegend, 336408, Alexa Fluor® 647 anti-human CD61 Antibody
100tests
Catalog Number: 336408
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| Verified Reactivity | Human, Cynomolgus, Rhesus |
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| Reported Reactivity | African Green, Baboon |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested ICC - Verified |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl volume or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
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| Excitation Laser | Red Laser (633 nm) |
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| Application Notes | Additional reported applications (for the relevant formats) include: Western blotting and immunohistochemical staining of frozen tissue sections. |
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| Application References(PubMed link indicates BioLegend citation) | Davies J, et al. 1989. J. Cell Biol. 109:1817. Roberts M, et al. 2004. Mol. Cell. Biol. 24:1505. Ciarlet M, et al. 2002. J. Virol. 76:1109. |
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| Product Citations | Garofano K, et al. 2023. Sci Rep. 13:2864. PubMed Zubairova L, et al. 2015. Sci Rep. 5: 17611. PubMed Murray KD, et al. 2021. Front Neurol. 11:595463. PubMed Artemenko E, et al. 2016. Biochem J. 473: 435 - 448. PubMed Singh MV, et al. 2020. J Leukoc Biol. 109:807. PubMed Dieterle ME, et al. 2021. Elife. 10:. PubMed |
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| RRID | AB_2128751 (BioLegend Cat. No. 336407) AB_2128750 (BioLegend Cat. No. 336408) |
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| Structure | Type I integral glycoprotein, integrin family, associates with CD41 (gpIIb) forming CD41/CD61 complex or with CD51 (integrin αV) forming CD51/CD61 complex, 90 kD |
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| Distribution | CD41/CD61 complex is expressed on platelets and megakaryocytes; CD51/CD61 complex is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells |
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| Function | Adhesion, platelet activation and aggregation |
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| Ligand/Receptor | Fibronectin, vitronectin, vWF |
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| Cell Type | Fibroblasts, Megakaryocytes, Osteoclasts, Platelets |
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| Biology Area | Immunology |
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| Molecular Family | Adhesion Molecules, CD Molecules |
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| Antigen References | 1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers. |
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| Gene ID | 3690 |
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| UniProt | View information about CD61 on UniProt.org |
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| Clone | VI-PL2 |
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| Regulatory Status | RUO |
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| Other Names | Integrin β3, gpIIIa |
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| Isotype | Mouse IgG1, κ |
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