Biolegend, 337221, Purified anti-human CD11c (Maxpar® Ready) Antibody
100microg
Catalog Number: 337221
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 1.0 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. |
| Application | FC - Quality tested CyTOF® - Verified |
| Recommended Usage | This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies. |
| Application Notes | Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes. |
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| Additional Product Notes |
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| Maxpar® is a registered trademark of Standard BioTools Inc. |
| Application References(PubMed link indicates BioLegend citation) | Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42. Rezzonico R, et al. 2001. Blood 97:2932. Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) |
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| Product Citations | Glass MC, et al. 2022. Cell Rep. 39:110728. PubMed Gadalla R, et al. 2022. STAR Protoc. 3:101643. PubMed Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed Gide TN, et al. 2019. Cancer Cell. 35:238. PubMed Dumas AA, et al. 2020. EMBO J. 39:e103790. PubMed Schulte–Schrepping J, et al. 2020. Cell. 182(6):1419-1440. PubMed Cheung P, et al. 2018. Cell. 173:1385. PubMed Jordan S, et al. 2020. Cell. 178(5):1102-1114.e17.. PubMed Georg P, et al. 2022. Cell. 185:493. PubMed Wimmers F, et al. 2021. Cell. 184:3915. PubMed |
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| RRID | AB_2562834 (BioLegend Cat. No. 337221) |
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| Structure | Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD |
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| Distribution | Myeloid, dendritic cells, NK cells, B cells and T cell subsets |
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| Function | Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen |
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| Cell Type | B cells, Dendritic cells, Neutrophils, NK cells, T cells |
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| Biology Area | Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | Adhesion Molecules, CD Molecules |
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| Antigen References | 1. Petty H. 1996. Immunol. Today 17:209. 2. Springer T. 1994. Cell 76:301. 3. Ihanus E, et al. 2007. Blood 109:802-810. |
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| Gene ID | 3687 |
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| UniProt | View information about CD11c on UniProt.org |
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| Clone | Bu15 |
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| Regulatory Status | RUO |
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| Workshop | V S143 |
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| Other Names | Integrin αx subunit, ITGAX, CR4, p150 |
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| Isotype | Mouse IgG1, κ |
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