Biolegend, 337235, Alexa Fluor® 488 anti-human CD11c Antibody
25tests
Catalog Number: 337235
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser |
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| Blue Laser (488 nm) |
| Application Notes | Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes. |
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| Application References(PubMed link indicates BioLegend citation) | Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42. Rezzonico R, et al. 2001. Blood 97:2932. Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) |
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| Product Citations | Flynn PA, et al. 2024. Front Immunol. 1297338:15. PubMed |
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| RRID | AB_2566657 (BioLegend Cat. No. 337235) AB_2566658 (BioLegend Cat. No. 337236) |
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| Structure | Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD |
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| Distribution | Myeloid, dendritic cells, NK cells, B cells and T cell subsets |
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| Function | Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen |
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| Cell Type | B cells, Dendritic cells, Neutrophils, NK cells, T cells |
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| Biology Area | Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | Adhesion Molecules, CD Molecules |
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| Antigen References | 1. Petty H. 1996. Immunol. Today 17:209. 2. Springer T. 1994. Cell 76:301. 3. Ihanus E, et al. 2007. Blood 109:802-810. |
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| Gene ID | 3687 |
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| UniProt | View information about CD11c on UniProt.org |
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| Clone | Bu15 |
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| Regulatory Status | RUO |
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| Workshop | V S143 |
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| Other Names | Integrin αx subunit, ITGAX, CR4, p150 |
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| Isotype | Mouse IgG1, κ |
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