Biolegend, 338328, Alexa Fluor® 647 anti-human CD226 (DNAM-1) Antibody
100tests
Catalog Number: 338328
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| Verified Reactivity | Human |
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| Reported Reactivity | African Green, Baboon, Cynomolgus, Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | ?Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Red Laser (633 nm) |
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| Application Notes |
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| Additional reported applications include: block NK cell-mediated lysis. |
| Application References(PubMed link indicates BioLegend citation) | Fuchs A, et al. 2004. J. Immunol. 172:3994. |
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| RRID | AB_2728297 (BioLegend Cat. No. 338327) AB_2728298 (BioLegend Cat. No. 338328) |
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| Structure | Ig domain containing adhesion molecule |
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| Distribution | Peripheral blood T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells |
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| Function | Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell |
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| Interaction | Interacts with LFA-1. |
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| Ligand/Receptor | PVR (CD155) and Nectin-2 (CD112) |
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| Cell Type | B cells, Macrophages, Megakaryocytes, Monocytes, NK cells, Platelets, T cells |
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| Biology Area | Immunology |
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| Molecular Family | CD Molecules |
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| Antigen References | 1. Shibuya A et al. 1996. Immunity 4:573. 2. Tahara-Hanaoka S et al. 2004. Int. Immunol. 16:533. 3. Pende D et al. 2005. Mol. Immunol. 42:463. |
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| Gene ID | 10666 |
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| UniProt | View information about CD226 on UniProt.org |
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| Clone | 11A8 |
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| Regulatory Status | RUO |
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| Other Names | DNAM-1, PTA1, TLiSA1 |
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| Isotype | Mouse IgG1, κ |
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