Biolegend, 345019, Purified anti-human CD366 (Tim-3) (Maxpar® Ready) Antibody
100microg
Catalog Number: 345019
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human Tim-3 fusion protein |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 1.0 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. |
| Application | FC - Quality tested CyTOF® - Verified |
| Recommended Usage | This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies. |
| Application Notes | Additional reported applications (for relevant formats of this clone) include: costimulation1 (clone 2E2 has been shown to enhance T-cell receptor mediated activation and cytokine secretion) and blocking2,3. |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
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| Additional Product Notes |
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| Maxpar® is a registered trademark of Standard BioTools Inc. |
| Application References(PubMed link indicates BioLegend citation) | Hastings WD, et al. 2009. Eur. J. Immunol. 39:2492. (Costim) Jones RB, et al. 2008. J. Exp. Med. 205:2763. (Block) Klibi J, et al 2009. Blood 113:1957. (FC, Block) |
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| Product Citations | Hezaveh K, et al. 2022. Immunity. 55:324. PubMed Gadalla R, et al. 2022. STAR Protoc. 3:101643. PubMed Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed Loo Yau H, et al. 2021. Molecular Cell. 81(7):1469-1483.e8. PubMed |
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| RRID | AB_2563790 (BioLegend Cat. No. 345019) |
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| Structure | Transmembrane protein containing immunoglobulin domain and mucin-like domain; can exist as a soluble form lacking mucin and transmembrane domains |
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| Distribution | Activated T cells, preferentially on Th1 cells, monocytes, dendritic cells |
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| Function | Plays a role in regulating macrophage activation, T cell apoptosis and immune tolerance |
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| Ligand/Receptor | Galectin-9 |
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| Cell Type | Dendritic cells, Monocytes, T cells, Th1, Tregs |
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| Biology Area | Immunology, Inhibitory Molecules |
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| Molecular Family | CD Molecules, Immune Checkpoint Receptors |
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| Antigen References | 1. Hafler DA and Kuchroo V. 2008. J. Exp. Med. 205:2699. 2. Zhu C, et al. 2005. Nat. Immunol. 6:1245. 3. Wang F, et al. 2009. Immunobiology 214:342. |
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| Gene ID | 84868 |
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| UniProt | View information about CD366 on UniProt.org |
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| Clone | F38-2E2 |
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| Regulatory Status | RUO |
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| Workshop | HCDM listed |
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| Other Names | T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2, CD366 |
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| Isotype | Mouse IgG1, κ |
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