Biolegend, 348613, Alexa Fluor® 647 anti-human CD243 (MDR-1) Antibody
25microg
Catalog Number: 348613
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| Verified Reactivity | Human |
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| Reported Reactivity | African Green, Baboon |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | NIH 3T3 cells transfected with human MDR-1 cDNA |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC, IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
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| Excitation Laser | Red Laser (633 nm) |
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| Application Notes | Additional reported applications (for the relevant formats) include: blocking the efflux of fluorescent dyes1,2, immunoprecipitation1, and immunohistochemical staining of tissue sections of squamous cell carcinoma3. |
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| Application References(PubMed link indicates BioLegend citation) | Mechetner EB and Roninson IB. 1992. Proc. Natl. Acad. Sci. USA 13:5824. (Block, IP) Chaudhary PM, et al. 1992. Blood 80:2735. (Block) Kelley DJ, et al. 1993. Arch. Otolaryngol. Head Neck Surg. 119:411. (IHC-P) Goda K, et al. 2007. J. Pharmacol. Exp. Ther. 320:81. (Block) |
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| RRID | AB_2734356 (BioLegend Cat. No. 348613) AB_2734357 (BioLegend Cat. No. 348614) |
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| Structure | Member of ABC transporters family, MW ~170 kD. Consists of two homologous halves, each comprising two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs). |
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| Distribution | Hematopoietic stem cells, T and B cells, natural killer (NK) cells, and many multidrug resistant neoplastic cells. |
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| Function | Transport various molecules across cellular membranes. Involved in multidrug resistance. |
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| Cell Type | B cells, Hematopoietic stem and progenitors, NK cells, T cells |
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| Biology Area | Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology |
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| Molecular Family | CD Molecules |
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| Antigen References | 1. Dulucq S, et al. 2008. Blood 112:2024. 2. Gottesman MM, et al. 2009. Nat. Biotechnol. 27:546. 3. Andreadis C, et al. 2007. Blood 109:3409. |
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| Gene ID | 5243 |
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| UniProt | View information about CD243 on UniProt.org |
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| Clone | UIC2 |
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| Regulatory Status | RUO |
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| Other Names | Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1 |
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| Isotype | Mouse IgG2a, κ |
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