Biolegend, 353212, APC/Cyanine7 anti-human CD197 (CCR7) Antibody
100tests
Catalog Number: 353212
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| Verified Reactivity | Human |
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| Reported Reactivity | African Green, Baboon, Cynomolgus, Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | CCR7-transfected cells |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. |
| Excitation Laser | Red Laser (633 nm) |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Product Citations |
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| Woodcock V, et al. 2023. BJUI Compass. 4:322. PubMed Toriyama M, et al. 2023. Front Mol Biosci. 10:1149828. PubMed Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed Mo Y, et al. 2022. Front Immunol. 12:799896. PubMed Touizer E, et al. 2023. iScience. 26:105862. PubMed Meng Q, et al. 2016. PLoS One. 11:e0166954. PubMed Wu VH, et al. 2020. JCI Insight. 5:00. PubMed Kim C, et al. 2018. Cell Rep. 25:2148. PubMed Xiao C, et al. 2022. iScience. 25:103934. PubMed Tauriainen J, et al. 2017. Sci Rep. 7:40354. PubMed Hinks TSC, et al. 2019. Cell Rep. 28:3249. PubMed Demers K, et al. 2016. PLoS Pathog. 12: 1005805. PubMed Hong J, et al. 2014. J Immunol. 193:797. PubMed Kuri-Cervantes L, et al. 2020. STAR Protoc. 1:100154. PubMed Uchtenhagen H, et al. 2016. Nat Commun. 7:12614. PubMed Jankeel A, et al. 2020. J Virol. :94. PubMed Japp AS, et al. 2021. Cell. 184(3):827-839.e14. PubMed Alrubayyi A, et al. 2021. Nat Commun. 12:5839. PubMed Kuo HH, et al. 2018. Immunity. 48:1183. PubMed Kim C, et al. 2019. Cell Rep. 29:2202. PubMed Xu S, et al. 2021. Immunity. . PubMed Pattekar A, et al. 2021. Cellular and Molecular Gastroenterology and Hepatology. 11(5):1267-1289. PubMed Buggert M, et al. 2020. Cell. 183(7):1946-1961.e15. PubMed Colomb F, et al. 2020. Cell Reports. 32(5):107991. PubMed Gao Y, et al. 2022. Immunity. 55:1732. PubMed Krishnan S, et al. 2021. Clin Exp Immunol. 203:458. PubMed Poon MML, et al. 2021. Cell Rep. 37:110071. PubMed Rasmussen TA, et al. 2022. Cell Rep Med. 3:100766. PubMed Le J, et al. 2020. Immunity. 52(6):1105-1118.e9. PubMed Sekine T, et al. 2020. Cell. 183:158. PubMed NULL, et al. 2022. Cell. 185:916. PubMed Shuwa HA, et al. 2021. Med. 2(6):720-735.e4. PubMed Meijgaarden K, et al. 2015. PLoS Pathog. 11:1004671. PubMed Crump NT, et al. 2021. Cell Reports. 35(6):109101. PubMed Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed Rusconi M, et al. 2017. Sci Rep. 5.745138889. PubMed Cortés–Rubio CN, et al. 2019. Clin Epigenetics. 11:134. PubMed |
| RRID | AB_10915272 (BioLegend Cat. No. 353211) AB_10916390 (BioLegend Cat. No. 353212) |
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| Structure | Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor. |
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| Distribution | T cells, B cells, NK, dendritic cells. |
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| Function | The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels. |
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| Ligand/Receptor | CCL19 and CCL21. |
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| Cell Type | B cells, Dendritic cells, NK cells, T cells |
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| Biology Area | Immunology |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors, GPCR |
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| Antigen References | 1. Yanagihara S, et al. 1998. J. Immunol. 161:3096. 2. Charo IF, et al. 2006. N. Engl. J. Med. 354:610. 3. Reif K, et al. 2002. Nature 416:94. 4. Nakata B, et al. 2008. Oncology 74:69. 5. Brodie T. et al. 2013. Cytometry A. 6: 530-2. PubMed 6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9 PubMed 7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8 PubMed |
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| Gene ID | 1236 |
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| UniProt | View information about CD197 on UniProt.org |
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| Clone | G043H7 |
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| Regulatory Status | RUO |
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| Other Names | BLR2, CDw197, EBI1, CMKBR7 |
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| Isotype | Mouse IgG2a, κ |
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