Biolegend, 353243, Alexa Fluor® 700 anti-human CD197 (CCR7) Antibody
25tests
Catalog Number: 353243
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| Verified Reactivity | Human |
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| Reported Reactivity | African Green, Baboon, Cynomolgus, Rhesus |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | CCR7-transfected cells |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
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| Excitation Laser | Red Laser (633 nm) |
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| Product Citations | Gkika E, et al. 2023. NPJ Precis Oncol. 7:24. PubMed Lima NS, et al. 2022. Nat Commun. 13:7733. PubMed Warmuth S, et al. 2022. Oncoimmunology. 10:2004661. PubMed Georg P, et al. 2022. Cell. 185:493. PubMed Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed |
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| RRID | AB_2617000 (BioLegend Cat. No. 353243) AB_2617001 (BioLegend Cat. No. 353244) |
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| Structure | Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor. |
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| Distribution | T cells, B cells, NK, dendritic cells. |
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| Function | The chemokine receptor CCR7 plays a pivotal role in the homing of naïve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels. |
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| Ligand/Receptor | CCL19 and CCL21. |
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| Cell Type | B cells, Dendritic cells, NK cells, T cells |
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| Biology Area | Immunology |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors, GPCR |
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| Antigen References | 1. Yanagihara S, et al. 1998. J. Immunol. 161:3096. 2. Charo IF, et al. 2006. N. Engl. J. Med. 354:610. 3. Reif K, et al. 2002. Nature 416:94. 4. Nakata B, et al. 2008. Oncology 74:69. 5. Brodie T. et al. 2013. Cytometry A. 6: 530-2. PubMed 6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9 PubMed 7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8 PubMed |
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| Gene ID | 1236 |
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| UniProt | View information about CD197 on UniProt.org |
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| Clone | G043H7 |
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| Regulatory Status | RUO |
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| Other Names | BLR2, CDw197, EBI1, CMKBR7 |
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| Isotype | Mouse IgG2a, κ |
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