Biolegend, 353711, Alexa Fluor® 647 anti-human CD183 (CXCR3) Antibody
25tests
Catalog Number: 353711
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| Verified Reactivity | Human, Cynomolgus, Rhesus |
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| Reported Reactivity | African Green, Baboon |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human CXCR3 transfectants |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Red Laser (633 nm) |
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| Product Citations | Barber-Axthelm IM, et al. 2023. iScience. 26:106269. PubMed Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed Balachandran H, et al. 2022. Cell Rep. 38:110345. PubMed Giles JR, et al. 2022. Immunity. 55:557. PubMed Woodruff M, et al. 2020. medRxiv. . PubMed Sekine T, et al. 2020. Cell. 183:158. PubMed Nobs SP, et al. 2017. J Exp Med. 214:3015. PubMed Cassotta A, et al. 2020. Eur J Immunol. . PubMed |
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| RRID | AB_10962946 (BioLegend Cat. No. 353711) AB_10962948 (BioLegend Cat. No. 353712) |
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| Structure | CXC-chemokine receptor, G protein-coupled receptor, seven-pass transmembrane receptor |
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| Distribution | T cell subset, NK cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors, mast cells, alveolar macrophages, eosinophils, and airway epithelial cells |
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| Function | Essential in T cell recruitment to sites of inflammation |
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| Ligand/Receptor | CXCL9, CXCL10, and CXCL11 |
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| Cell Type | Dendritic cells, Eosinophils, Epithelial cells, Hematopoietic stem and progenitors, Macrophages, Mast cells, NK cells, T cells, Tregs |
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| Biology Area | Cell Biology, Immunology, Neuroinflammation, Neuroscience |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors, GPCR |
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| Antigen References | 1. Loetscher M, et al. 1996. J. Exp. Med. 184:963. 2. Cole KE, et al. 1998. J. Exp. Med. 187:2009. 3. Aksoy MO, et al. 2006. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L909. 4. Curbishley SM, et al. 2005. Am. J. Pathol. 167:887. 5. Turner JE, et al. 2007. Mini. Rev. Med. Chem. 7:1089. 6. Wenzel J, et al. 2008. J. Invest. Dermatol. 128:67. |
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| Gene ID | 2833 |
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| UniProt | View information about CD183 on UniProt.org |
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| Clone | G025H7 |
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| Regulatory Status | RUO |
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| Other Names | CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2 |
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| Isotype | Mouse IgG1, κ |
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