Biolegend, 355116, Alexa Fluor® 647 anti-human CD70 Antibody
100tests
Catalog Number: 355116
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | CD70-transfected L cells |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
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| Excitation Laser | Red Laser (633 nm) |
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| Application Notes | Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1. |
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| Application References(PubMed link indicates BioLegend citation) | Shaw J, et al. 2010. Blood 115:3051. (Block) |
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| RRID | AB_2687256 (BioLegend Cat. No. 355115) AB_2687257 (BioLegend Cat. No. 355116) |
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| Structure | Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD |
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| Distribution | Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas |
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| Function | Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation |
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| Ligand/Receptor | CD27 |
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| Cell Type | B cells, Dendritic cells, NK cells, T cells |
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| Biology Area | Costimulatory Molecules, Immunology |
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| Molecular Family | CD Molecules |
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| Antigen References | 1. Bowman MR, et al. 1994. J. Immunol. 152:1756. 2. Shaw J, et al. 2010. Blood 115:3051. 3. Keller AM, et al. 2009. Blood 113:5167. |
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| Gene ID | 970 |
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| UniProt | View information about CD70 on UniProt.org |
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| Clone | 113-16 |
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| Regulatory Status | RUO |
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| Other Names | CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7) |
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| Isotype | Mouse IgG1, κ |
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