Biolegend, 359104, Alexa Fluor® 488 anti-human CD195 (CCR5) Antibody
100tests
Catalog Number: 359104
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Human CCR5 transfectants |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
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| Excitation Laser | Blue Laser (488 nm) |
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| Product Citations | Burke Schinkel SC, et al. 2024. Front Immunol. 1336480:15. PubMed Simula L, et al. 2024. Nat Commun. 2203:15. PubMed |
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| RRID | AB_2562312 (BioLegend Cat. No. 359103) AB_2562313 (BioLegend Cat. No. 359104) |
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| Structure | G-coupled receptor family 1, membrane protein, 45 kD |
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| Distribution | Subset of T cells, monocytes |
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| Function | Binds C-C chemokines and transduces an intracellular signal thought to result in proliferation and differentiation, acts as a co-receptor with CD4 for HIV-1 |
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| Ligand/Receptor | MIP-1α, MIP-1β, RANTES |
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| Cell Type | Monocytes, T cells |
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| Biology Area | Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience |
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| Molecular Family | CD Molecules, Cytokine/Chemokine Receptors, GPCR |
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| Antigen References | 1. Samson M, et al. 1996. Biochemistry 35:3362. 2. Raport CJ, et al. 1996. J. Biol. Chem. 271:17161. 3. Combadiere C, et al. 1996. J. Leukoc. Biol. 60:147. 4. Deng H, et al. 1996. Nature 381:661. 5. Lai J, et al. 2003. CVI. 10:1123. 6. Mañes S, et al. 2003. J. Exp. Med. 198:1381. 7. Vaday GG, et al. 2006. Prostate 66:124. |
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| Gene ID | 1234 |
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| UniProt | View information about CD195 on UniProt.org |
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| Clone | J418F1 |
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| Regulatory Status | RUO |
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| Other Names | C-C chemokine receptor type 5 (CCR5), HIV-1 fusion co-receptor |
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| Isotype | Rat IgG2b, κ |
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