Biolegend, 361703, Alexa Fluor® 647 anti-human HLA-DR, DP, DQ Antibody
25tests
Catalog Number: 361703
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| Verified Reactivity | Human |
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| Reported Reactivity | Baboon, Cynomolgus, Cat, Dog, Cow |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human PBL |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Red Laser (633 nm) |
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| Application Notes | Tü39 has been reported to react with a shared epitope of HLA-DR, HLA-DP, and HLA-DQ. Additional reported applications (of relevant formats) include immunoprecipitation6, in vitro blocking of MLR5, and suppressor cell generation4. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (contact our custom solutions team). |
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| Application References(PubMed link indicates BioLegend citation) | Pawelec G, et al. 1985. Hum. Immunol. 12:165. Shaw S, et al. 1985. Hum. Immunol. 12:191. Ziegler A, et al. 1986. Immunobiology 171:77. Pawelec G, et al. 1986. Hum. Immunol. 17:343. (Block) Dai Z, et al. 2009. J. Exp. Med. 206:793. (Block) Pawelec G, et al. 1988. J. Exp. Med. 167:243. (IP) |
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| Product Citations | Chimienti R, et al. 2022. Cell Rep. 40:111423. PubMed Dekker J, et al. 2016. Proc Natl Acad Sci U S A. 113: 577 - 586. PubMed Delitto D, et al. 2015. Cancer Immunol Immunother. 64: 1553-63. PubMed |
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| RRID | AB_2563168 (BioLegend Cat. No. 361703) AB_2563169 (BioLegend Cat. No. 361704) |
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| Structure | Ig superfamily, MHC class II, heterodimeric transmembrane protein |
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| Distribution | B cells, activated T cells, monocytes/macrophages, dendritic cells, other APCs |
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| Function | Antigen presentation |
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| Ligand/Receptor | CD3/TCR, CD4 |
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| Cell Type | Antigen-presenting cells, B cells, Dendritic cells, Macrophages, Monocytes, T cells |
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| Biology Area | Immunology, Innate Immunity |
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| Molecular Family | MHC Antigens |
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| Antigen References | 1. Thorsby E. 1974. Transplant. Rev. 18:51. 2. Qvigstad E, et al. 1984. Hum. Immunol. 11:207. 3. Servenius B, et al. 1984. EMBO J. 3:3209. 4. Ottenhoff TH, et al. 1985. Hum. Immunol. 13:105. 5. Strassmann G, et al. 1985. Hum. Immunol. 13:125. 6. Trowsdale J, et al. 1985. Immunol Rev. 85:5. |
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| Gene ID | 312231233113311531173119 |
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| UniProt | View information about HLA-DR DP DQ on UniProt.org |
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| Clone | Tü39 |
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| Regulatory Status | RUO |
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| Other Names | MHC class II, Major Histocompatibility complex II, human leukocyte antigen, HLA |
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| Isotype | Mouse IgG2a, κ |
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