Biolegend, 368405, Brilliant Violet 421™ anti-human Ikaros Antibody
25tests
Catalog Number: 368405
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human Ikaros peptide (431-477 aa) conjugated to KLH Freund's adjuvant. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA). |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | ICFC - Quality tested |
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| Recommended Usage |
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| Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. |
| Excitation Laser | Violet Laser (405 nm) |
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| Application Notes | There are eight splicing variants with predicted MW 58, 53, 48(2), 43, 41, 31, 24 KDa. This antibody might recognize some of the isoforms. |
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| RRID | AB_2571956 (BioLegend Cat. No. 368405) AB_2571957 (BioLegend Cat. No. 368406) |
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| Structure | Zinc-finger DNA binding protein, homo/heterodimer, 57.5 kD |
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| Distribution | Fetal and adult hematopoietic cells. |
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| Function | Regulates lymphocyte differentiation. |
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| Interaction | DNA. |
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| Cell Type | B cells, Dendritic cells |
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| Biology Area | Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Signal Transduction, Transcription Factors |
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| Molecular Family | Nuclear Markers |
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| Antigen References | 1. Wargnier A, et al. 1995. Proc. Natl. Acad. Sci. USA 92:6930. 2. Tonnelle C, et al. 2009. Mol. Immunol. 46:1736. 3. Wang H, et al. 2014. Pediatr. Blood Cancer 61:2230. |
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| Gene ID | 10320 |
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| UniProt | View information about Ikaros on UniProt.org |
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| Clone | 16B5C71 |
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| Regulatory Status | RUO |
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| Other Names | IK1, IKZF1 |
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| Isotype | Mouse IgG2a, κ |
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