Biolegend, 369819, Alexa Fluor® 647 anti-human CD326 (EpCAM) Antibody
25tests
Catalog Number: 369819
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser |
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| Red Laser (633 nm) |
| Application References(PubMed link indicates BioLegend citation) | Strnad J, et al. 1989. Cancer Res. 49:314. Munz M, et al. 2004. Oncogene 23:5748. Rao CG, et al. 2005. Int. J. Oncol. 27:49. |
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| Product Citations | Carraro G, et al. 2021. Nat Med. 27:806. PubMed Carraro G, et al. 2020. Am J Respir Crit Care Med. 202:1540. PubMed |
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| RRID | AB_2650915 (BioLegend Cat. No. 369819) AB_2650916 (BioLegend Cat. No. 369820) |
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| Structure | Type I transmembrane protein, contains six disulfide bridges, one THYRO domain, approximate molecular weight 40 kD. |
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| Distribution | Highly expressed in bone marrow, colon, lung, and most normal epithelial cells. Also highly expressed on carcinomas of gastrointestinal origin. Expressed during early erythrogenesis. |
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| Function | Homotypic calcium-independent cell adhesion. CD326 is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. |
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| Cell Type | Epithelial cells |
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| Biology Area | Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability, Immunology |
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| Molecular Family | Adhesion Molecules, CD Molecules |
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| Antigen References | 1. Strnad J, et al. 1989. Cancer Res. 49:314. 2. Munz M, et al. 2004. Oncogene 23:5748. 3. Rao CG, et al. 2005. Int. J. Oncol. 27:49. |
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| Gene ID | 4072 |
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| UniProt | View information about CD326 on UniProt.org |
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| Clone | CO17-1A |
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| Regulatory Status | RUO |
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| Other Names | Ep-CAM, tumor associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2, EGP2, adenocarcinoma associated antigen, TROP1 |
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| Isotype | Mouse IgG2a, κ |
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