Biolegend, 377707, Alexa Fluor® 594 anti-human CD45RB Recombinant Antibody
25microg
Catalog Number: 377707
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| Verified Reactivity | Human |
|---|---|
| Antibody Type | Recombinant |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. |
| Concentration | 0.5 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Application Notes | Clone QA20A68 can completely block the binding of MEM-55 to target cells. |
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| RRID |
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| AB_3683410 (BioLegend Cat. No. 377707) AB_3683410 (BioLegend Cat. No. 377708) |
| Structure | Tyrosine phosphatases, type I transmembrane, 180-240 kD (exon 5 splicing of CD45 gene) |
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| Distribution | Highly expressed in bone marrow, colon, lung, and most normal epithelial cells. Also highly expressed on carcinomas of gastrointestinal origin. Expressed during early erythrogenesis. |
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| Function | Enhances TCR and BCR signaling. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. |
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| Interaction | Human |
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| Ligand/Receptor | Galectin-1, CD2, CD3, CD4 |
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| Cell Type | B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, T cells, Thymocytes, Tregs |
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| Biology Area | Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | CD Molecules |
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| Antigen References | Thomas ML. 1989. Annu Rev Immunol. 7:339-69. Trowbridge IS, et al. 1994. Annu Rev Immunol.12:85-116. |
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| Gene ID | 5788 |
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| UniProt | View information about CD45RB on UniProt.org |
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| Clone | QA20A68 |
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| Regulatory Status | RUO |
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| Isotype | Mouse IgG1, κ |
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