Biolegend, 396303, Alexa Fluor® 647 anti-human CD19 Antibody
25microg
Catalog Number: 396303
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Recombinant human CD19 |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Red Laser (633 nm) |
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| Product Citations |
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| O'Connor MH, et al. 2021. Commun Biol. 4:563. PubMed |
| RRID | AB_2801070 (BioLegend Cat. No. 396303) AB_2801071 (BioLegend Cat. No. 396304) |
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| Structure | Ig superfamily, type I transmembrane glycoprotein, 95 kD |
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| Distribution | Normal and malignant B lymphocytes |
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| Function | B cell activation and differentiation |
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| Interaction | Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells and interacts with VAV and LYN. It also interacts with GRAB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378 and with PLCG2 when phosphorylated on Tyr-409. |
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| Ligand/Receptor | Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor |
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| Cell Type | B cells, Lymphocytes |
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| Biology Area | Costimulatory Molecules, Immunology |
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| Molecular Family | CD Molecules |
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| Antigen References | Tedder T, et al. 1994. Immunol Today. 15:437. Bradbury L, et al. 1993. J Immunol. 151:2915. |
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| Gene ID | 930 |
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| UniProt | View information about CD19 on UniProt.org |
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| Clone | A17136C |
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| Regulatory Status | RUO |
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| Other Names | B4, CVID3 |
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| Isotype | Mouse IgG2b, κ |
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