Biolegend, 399104, Alexa Fluor® 647 anti-human CD339 (Jagged 1) Antibody
100tests
Catalog Number: 399104
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Human Jagged-transfected RBL1 cells |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
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| Excitation Laser | Red Laser (633 nm) |
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| RRID | AB_2890847 (BioLegend Cat. No. 399103) AB_2890847 (BioLegend Cat. No. 399104) |
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| Structure | A 135 kD type 1 transmembrane protein with 1 DSL domain, 15 EGF-like domain and 1 cysteine-rich region. |
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| Distribution | Macrophages, subset of dendritic cells, astrocytes, stromal and epithelial cells. |
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| Function | Regulate cell fate decisions in tissues, neurogenesis, Th2 polarization, and Treg induction |
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| Ligand/Receptor | Notch |
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| Cell Type | Astrocytes, Dendritic cells, Epithelial cells, Macrophages, Monocytes |
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| Biology Area | Cardiovascular Biology, Immunology, Neuroscience |
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| Molecular Family | CD Molecules |
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| Antigen References | Oda T, et al. 1997. Nat. Genet. 16:235. Li L, et al. 1997. Nat. Genet. 16:243. Guarnaccia C, et al. 2004. FEBS Letters. 574:156. High FA, et al. 2008. Proc. Natl. Acad. Sci. 105:1955. Kopan R and Ilagan MX. 2009. Cell. 137:216. Reedijk M, et al. 2005. Cancer Res. 65:8530. Grochowski CM, et al. 2016. Gene. 576:381. Hofmann JJ, et al. 2012. Development. 139:4449. |
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| Gene ID | 182 |
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| UniProt | View information about CD339 on UniProt.org |
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| Clone | W16199B |
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| Regulatory Status | RUO |
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| Other Names | JAG1, Jag-1, Jagged1, Jagged-1 |
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| Isotype | Rat IgG2a, κ |
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