Biolegend, 431317, LEGEND MAX™ High Sensitivity Mouse IL-6 ELISA Kit

Mouse IL-6 (interleukin 6, also known as B-cell differentiation factor, B-cell stimulatory factor 2, interferon β-2, hybridoma growth factor, and cytotoxic T-lymphocyte differentiation factor) plays an essential role in the final differentiation of B-cells into immunoglobin-secreting cells. Also, it induces myeloma and plasmacytoma growth, promotes nerve cell differentiation, and (in hepatocytes) induces acute phase reactant proteins. IL-6 is expressed by T cells, B cells, monocytes, fibroblasts, hepatocytes, endothelial cells, and keratinocytes. Current research suggests that IL-6 plays a critical role in many physiological and pathological conditions, including autoimmune diseases and rheumatoid arthritis. The BioLegend LEGEND MAX™ High Sensitivity Mouse IL-6 ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a monoclonal anti-mouse IL-6 capture antibody. The detection antibody is a biotinylated monoclonal anti-mouse IL-6 antibody. After washing away any unbound biotinylated detection antibody, a streptavidin-polymer HRP is used for detection. Streptavidin-Polymer HRP enhances the sensitivity of the kit, allowing for detection of low concentrations of IL-6. This kit is specifically designed for the accurate quantitation of mouse IL-6 in serum, heparin plasma, and cell culture supernatant. This kit is analytically validated with ready-to-use reagents.