Biolegend, 437014, ELISA MAX™ Deluxe Set Human Pro IL-1β

IL-1 refers to two proteins (IL-1α and IL-1β), which are the products of distinct genes that are recognized by the same cell surface receptors. Human IL-1β is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses, including the activation of B and T cells. Pro-IL-1β is converted to its mature form through proteolytic cleavage by caspase-1 (also known as IL-1β-converting enzyme or ICE). This intracellular processing produces the mature active peptide that can be secreted and represents a key step in the inflammatory response. IL-1β  is expressed in several cell types, including monocytes, tissue macrophages, Langerhan cells, dendritic cells, T lymphocytes, B lymphocytes and natural killer cells. IL-1β plays a pathogenic role in Type 1 and Type 2 diabetes, rheumatoid arthritis, and osteoarthritis among other diseases. BioLegend’s ELISA MAX™ Deluxe Set Pro IL-1β contains the components necessary for the accurate quantification of natural and recombinant pro-IL-1β. The set is designed for cost-effective and accurate quantification of human pro-IL-1β in cell lysate samples. BioLegend’s ELISA MAX™ Deluxe Sets are sensitive, accurate, and robust.