Biolegend, 441107, LEGEND MAX™ Human CCL17 (TARC) ELISA Kit

Human CCL17, also known as thymus and activation regulated chemokine (TARC), was initially isolated from phytohemagglutinin-stimulated peripheral blood mononuclear cells. CCL17 is constitutively expressed in the thymus and under activation in several cell types. CCL17-mediated recruitment of Th 2 cells and CLA+ CD4+ T cells plays a key role in allergic diseases such as atopic dermatitis, allergic asthma, allergic rhinitis, and allergic contact dermatitis. In addition, CCL17 has been detected in idiopathic pulmonary fibrosis. CCL17 and CCL22 secreted by dendritic cells (DCs) seems to mediate the recruitment of regulatory T cells to sites of inflammation in patients with chronic hepatitis. CCL17 is upregulated under several conditions: TNF-a, IL-4, and IFN-? in bronchial epithelial cells; TGF-ß1, TNF-a, and IFN-? in human keratinocyte cell lines; and histamine and prostaglandin E2P in immature DCs. BioLegend's LEGEND MAX™ Human CCL17 (TARC) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with an antibody specific for human CCL17. This kit is specifically designed for the accurate quantitation of human CCL17 from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.