Biolegend, 448704, ELISA MAX™ Deluxe Set Human Amyloid Beta (1-42)

The Amyloid peptides are peptides of 36-43 amino acids which are produced through the post-translational cleavage of the Amyloid Precursor Protein by beta and gamma secretase. Although numerous different Amyloid-Beta species exist, the majority of the Amyloid-Beta peptides produced by post-translational modification consists of either Amyloid-Beta (1-40) (80-90%) and Amyloid-Beta (1-42) (5-10%). Both variants are major components of the extracellular plaques found in Alzheimer’s brain. However, Amyloid-Beta (1-42) is reported to be more prone to aggregation than the (1-40) variant despite differing in only 2 amino acids at the C terminus. Other studies that aimed at characterizing the difference in aggregation tendency between the two variants suggested that they have distinct 3D structures in solution. BioLegend’s ELISA MAX™ Deluxe Set is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA). The kit contains a monoclonal capture antibody and biotinylated monoclonal antibody specific for human Amyloid-Beta (1-42). This kit is specifically designed for the accurate quantitation of human Amyloid-Beta (1-42) in cerebrospinal fluid, serum and plasma. BioLegend’s ELISA MAX™ Deluxe Sets are sensitive, accurate, and robust.