Biolegend, 448707, LEGEND MAX™ Human Amyloid Beta (1-42) ELISA Kit

The Amyloid peptides are peptides of 36-43 amino acids which are produced through the post-translational cleavage of the Amyloid Precursor Protein by beta and gamma secretase. Although numerous different Amyloid beta species exist, the majority of the Amyloid Beta peptides produced by post-translational modification consists of either Amyloid Beta (1-40) (80-90%) and Amyloid Beta (1-42) (5-10%). Both variants are major components of the extracellular plaques found in Alzheimer’s disease brain. However, Amyloid Beta (1-42) was reported to be more prone to aggregation than the 1-40 variant despite differing in only 2 amino acids at the C terminus. Other studies that aimed at characterizing the difference in aggregation tendency between the two variants suggest that they have distinct 3D structures in solution. The LEGEND MAX™ Human Amyloid Beta (1-42) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with anti-human Amyloid Beta (1-42) antibody. The detection antibody is a biotinylated anti-human Amyloid Beta (1-42) monoclonal antibody. This kit is specifically designed for the accurate quantitation of human Amyloid Beta (1-42) from cerebrospinal fluid, serum, plasma, and tissue lysate. It is analytically validated with ready-to-use reagents.