Biolegend, 448807, LEGEND MAX™ Human α-Synuclein Aggregate ELISA Kit

α-Synuclein is a neuronal protein which plays a critical role in regulating the trafficking of pre-synaptic vesicles through interaction with the SNARE complex. In healthy neurons, α-Synuclein exists mainly as a monomeric protein. Within a diseased cell, however, α-Synuclein aggregates to form insoluble fibril which is toxic to the cell. In fact, the aggregated form of the α-Synuclein is the major constituent of the Lewy body inclusion, which is the hallmark of Parkinson’s disease, dementia with Lewy body, and other α-Synuclein-related neurodegenerative diseases. The formation and accumulation of α-Synuclein aggregate could impair many cellular processes from DNA repair to the release of neurotransmitters. Detection of α-Synuclein aggregate in the cerebrospinal fluid has been shown to have the potential to enhance the diagnosis of Parkinson’s disease and other α-Synuclein associated disorders. The LEGEND MAX™ Human α-Synuclein Aggregate ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with anti-human α-Synuclein Aggregate antibody. The detection antibody is a biotinylated anti-human α-Synuclein monoclonal antibody. This kit is specifically designed for the accurate quantitation of human α-Synuclein Aggregate in cerebrospinal fluid and tissue lysate. It is analytically validated with ready-to-use reagents.