Biolegend, 449804, ELISA MAX™ Deluxe Set Human Phospho-EGFR (Tyr845)

EGFR (Epidermal Growth Factor Receptor) is a member of the ErbB family of cell surface receptors. It is an oncoprotein which has been found to have increased expression and activity in multiple cancer types. However, low activity of EGFR can result in degenerative diseases such as Alzheimer’s disease. EGFR signaling pathway starts when it binds to the ligand EGF, resulting in receptor dimerization, transphosphorylation of the C-terminal tails, and propagation of the signal downstream. Each phosphorylation site can serve as a docking site for different proteins of different signaling pathways. Phosphorylation of tyrosine 845 is associated with regulation of receptor function and tumor progression via c-Src in a Zn2+-dependent manner. BioLegend’s ELISA MAX™ Deluxe Set contains the components necessary for the accurate quantification of natural and recombinant human Phospho-EGFR (Tyr845). The set is designed for cost-effective and accurate quantification of human Phospho-EGFR (Tyr845) in cell and tissue lysates. BioLegend’s ELISA MAX™ Deluxe Sets are sensitive, accurate, and robust.