Biolegend, 565504, Biotinylated Recombinant Human FOLR1 (carrier-free)

Name: Biotinylated Recombinant Human FOLR1 (carrier-free)
Brand: Biolegend
SKU: 565504

25microg

Catalog Number: 565504

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Category

Cell Lysis Buffers

Description

FOLR1, also known as folate receptor alpha, is a glycosylphosphatidylinositol (GPI)-anchored cell-surface glycoprotein encoded by the FOLR1 gene. FOLR1 binds with high affinity to folic acid and its derivatives and mediates cellular processes, including cell division, proliferation, and tissue growth via signaling cascades and components of the folate cycle. Each FOLR only binds one folate and brings the folate into cells via endocytosis of the FOLR-folate complex. Human FOLR1 shares 83% amino acid sequence homology with mouse and rat FOLR1. FOLR1, the most extensively studied isoform, has limited tissue expression but is overexpressed in several tumors of epithelial origin including ovarian cancer, non-small cell lung adenocarcinoma, breast cancer, renal cancer and endometrial cancer. The overexpression of FOLR1 is often associated with increased cancer progression and poor patient prognosis. It plays a critical role during embryogenesis.

Specifications

General

Source	Human FOLR1, amino acid (Arg25-Met233) (Accession: # P15328) with a C-terminal 8His and Avi tag, was expressed in CHO cells.
Molecular Mass	The 246 amino acid recombinant protein has a predicted molecular mass of approximately 28.4 kD. The DTT-reduced and non-reduced protein migrates at approximately 35-45 kD and 35-40 kD respectively as determined by SDS-PAGE. The predicted N-terminal amino acid is Arg.
Purity	> 95%, as determined by Coomassie stained SDS-PAGE.
Formulation	0.22 µm filtered protein solution is in PBS, pH 7.2
Endotoxin Level	Less than 0.1 EU per µg cytokine as determined by the LAL method.
Concentration	25 µg size is bottled at 200 µg/mL. 100 µg size and larger sizes are lot-specific and bottled at the concentration indicated on the vial. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to six months, or at -70°C or colder until the expiration date. For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored at -20°C or colder. Stock solutions can also be prepared at 50 - 100 µg/mL in appropriate sterile buffer, carrier protein such as 0.2 - 1% BSA or HSA can be added when preparing the stock solution. Aliquots can be stored between 2°C and 8°C for up to one week and stored at - 20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Ordering

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Biolegend, 565504, Biotinylated Recombinant Human FOLR1 (carrier-free)

Send an RFQ.

General

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