Biolegend, 579106, Biotinylated Recombinant Human NKP30/NCR3-Fc Chimera (carrier-free)

NKp30 (activating natural killer receptor NKp30), also known as CD337 and Natural Cytotoxicity Triggering Receptor 3 (NCR3), is a member of the natural cytotoxicity receptor (NCR) family. The NCR family are comprised of three type I transmembrane receptors that are expressed almost exclusively by NK cells, includes NKp30, NKp44, and NKp46. NKp30 is a 30 kDa glycosylated protein having one extracellular immunoglobulin-like domain and a hydrophobic TM domain. Six isoforms of NKp30 can be produced by alternative splicing, termed NKp30a-f. NKp30 is expressed on all mature resting and activated NK cells. NKp30 plays an important role in triggering NK cell cytolytic activity. It can enhance NK cell cytolysis of tumor cells that are deficient in MHC class I molecules, either independently or in cooperation with NKp44 and/or NKp46. NKp30 has been reported to have a unique role in NK-mediated lysis of immature dendritic cells. NK cells can kill autologous immature dendritic cells via ligation of NKp30. Alternately, NK cells can also promote the maturation of immature dendritic cells through engagement of NKp30. Heparan Sulfate Glycosaminoglycans, B7-H6, HLA-B-associated transcript 3 (BAT3)/Bcl2-associated anthogene 6 (BAG6), and Galectin-3 were identified as ligands for NKp30. Nkp30 can associate with T cell CD3 receptor zeta (TCRζ) and/or FcRγ via its TM domain with a charged arginine residue. NKp30 also has been shown to associate with CD59. NKp30 may serve as a potential target for therapeutics for cancers, autoimmune, disease atopic diseases, and Infectious diseases.