Biolegend, 596955, Biotinylated Recombinant Human SIRPG (carrier-free)

SIRPG or SIRP-gamma or SIRPγ (signal-regulatory protein γ) is a receptor protein involved in the negative regulation of receptor tyrosine kinase coupled signaling processes. It has been suggested that SIRPG signaling may play an immunoregulatory role in maintaining peripheral immune tolerance and preventing autoimmunity. SIRPG which has the same ligand that is, CD47 as SIRPα, expressed on T cells and activated NK cells. SIRPG-CD47 interaction mediates cell-cell adhesion and supports APC-T cell contact, enhancing antigen presentation, the consequent T cell proliferation and cytokine secretion. It seems unlikely that SIRPG itself generates intracellular signals because it does not have any recognizable signaling motifs. Instead, SIRPG may trigger signaling of CD47 in APCs. Although SIRPG is the only member of the SIRP family with known T1D (type I diabetes) risk loci, other proteins found in this family, such as SIRPα and SIRPβ1, may also be involved in ‘Type 1 Diabetes’ pathogenesis. The high expression of SIRPG is significantly associated with both T1D and LP (Lichen planus, a common chronic inflammatory skin disease) and this upregulation of SIRPG may exacerbate disease progression by regulating immune responses, promoting inflammation and causing tissue damage.