Biolegend, 601607, Alexa Fluor® 647 anti-human Cytokeratin 7 Antibody
25microg
Catalog Number: 601607
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Human KRT7 peptide (446-462) conjugated to KLH. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | ICC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.5 - 2.0 μg/ml (1:250-1:1000 dilution) is recommended. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Red Laser (633 nm) |
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| Application Notes |
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| This antibody does not react with mouse (in-house tested). Additional reported applications (for the relevant formats) include: spatial biology (IBEX)1,2. |
| Application References(PubMed link indicates BioLegend citation) | Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed |
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| RRID | AB_2728460 (BioLegend Cat. No. 601607) AB_2728461 (BioLegend Cat. No. 601608) |
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| Structure | Type II cytokeratin. 469 amino acids with a predicted molecular weight of 51 kD. |
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| Distribution | Cytoplasm. |
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| Function | KRT7 is a type II keratin, involved in the translational regulation of the human papillomavirus type 16 E7 mRNA. |
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| Interaction | KRT7 interacts with EIF3S10, HPV16 E7, and GPER1. |
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| Biology Area | Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | Intermediate Filaments |
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| Antigen References | 1. Tajima Y, et al. 2017. Sci Rep. 7:40684. 2. Huang B, et al. 2016. Oncogene. 35:4927. 3. Szponar A, et al. 2012. Virchows Arch. 460:423. 4. Sano M, et al. 2010. Int J Oncol. 36:321. |
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| Gene ID | 3855 |
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| UniProt | View information about Cytokeratin 7 on UniProt.org |
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| Clone | W16155A |
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| Regulatory Status | RUO |
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| Other Names | Keratin type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Type-II keratin Kb7, Sarcolectin, SCL, Cytokeratin 7, Keratin 7 |
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| Isotype | Rat IgG2a, κ |
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