Biolegend, 640654, Ultra-LEAF™ Purified anti-human BMP12/GDF-7 Antibody
1mg
Catalog Number: 640654
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Recombinant Human BMP12/GDF-7 |
| Formulation | 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. |
| Endotoxin Level | Less than 0.01 EU/μg of the protein (< 0.001 ng/μg of the protein) as determined by the LAL test |
| Preparation | The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography. |
| Concentration | The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool. |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions. |
| Application | Neut - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by neutralizing the ALP activity induced by 4 μg/mL of Recombinant Human BMP12/GDF-7 in ATDC-5 cells. ND50 range: 3 – 18 μg/mL. |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| RRID |
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| AB_3717170 (BioLegend Cat. No. 640653) AB_3717170 (BioLegend Cat. No. 640654) |
| Structure | Dimer |
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| Distribution | Tenoblast, mesenchymal cells, pericytes in the endotenon, tendon fibroblasts |
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| Function | BMP12 promotes cell growth and stem cell tenogenic differentiation in bone marrow MSCs. Key role in the development of interneurons, sensory neurons, and seminal vesicles. |
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| Interaction | Bone marrow mesenchymal stem cells (MSCs), adipose derived MSCs, neurons |
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| Ligand/Receptor | Type I (BMPR-IB) and type II (BMPR-II or Activin RII) |
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| Cell Type | Mesenchymal cells, Neurons |
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| Biology Area | Neuroscience |
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| Molecular Family | Growth Factors |
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| Antigen References | Lou J, et al. 2001. J Orthop Res. 6:1199-202. Fu SC, et al. 2003. Life Sci. 72:2965-74. Mazerbourg S, et al. 2005. J Biol. Chem. 280: 32122-32. Lo L, et al. 2005. Proc Natl Acad Sci U S A. 102:7192-97. Eliasson P, et al. 2008. Clin Orthop Relat Res. 466:1592-97. Lee JY, et al. 2011. PLoS One. 6:e17531. Gelberman RH, et al. 2017. Clin Orthop Relat Res. 475:2318-331. |
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| Gene ID | 151449 |
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| UniProt | View information about BMP12/ GDF-7 on UniProt.org |
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| Clone | W23031A |
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| Regulatory Status | RUO |
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| Other Names | Growth Differentiation Factor 7, GDF7, GDF-7, BMP-12 |
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| Isotype | Rat IgG2a, κ |
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