Biolegend, 648003, Alexa Fluor® 488 anti-Hsp70 Antibody
25tests
Catalog Number: 648003
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| Verified Reactivity | Human, Mouse |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Hsp70 protein from HeLa cells. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | ICFC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Excitation Laser | Blue Laser (488 nm) |
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| Product Citations | Tsai KC, et al. 2023. Mar Drugs. 21:. PubMed Gilazieva Z, et al. 2022. Curr Issues Mol Biol. 44:5363. PubMed Chulpanova DS, et al. 2023. Curr Issues Mol Biol. 45:571. PubMed Salybekov AA, et al. 2021. Front Cardiovasc Med. 8:754254. PubMed Mouratidis PXE, et al. 2021. Int J Hyperthermia. 38:1443. PubMed Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed Kırbaş OK, et al. 2019. Sci Rep. 9:19159. PubMed |
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| RRID | AB_2119539 (BioLegend Cat. No. 648003) AB_2119537 (BioLegend Cat. No. 648004) |
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| Structure | Hsp proteins are the most conserved proteins present in both prokaryotes and eukaryotes. Human HSp70 contains multiple isoforms. Hsp70s consisit of three structural domains, a 44Kd amino-terminal ATPase domain (NBD), followed by an 18 Kd substrate |
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| Distribution | Ubiquitous, cytoplasmic and nuclear |
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| Function | Molecular chaperrones assisting in the folding of proteins and preventing protein aggregation |
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| Biology Area | Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance |
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| Antigen References | 1. Sharma D, et al. 2009. Protein Peptide Lett. 16:571. 2. Johnson JD, et al. 2006. J. Leuk. Biol. 79:425. 3. Bukau B, et al. 1998. Cell 92:351. |
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| Gene ID | 3308 |
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| UniProt | View information about Hsp70 on UniProt.org |
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| Clone | W27 |
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| Regulatory Status | RUO |
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| Other Names | Heat shock protein 70 |
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| Isotype | Mouse IgG2a, λ |
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