Biolegend, 660052, Purified anti-Acetyl-CoA Carboxylase alpha Phospho (Ser79) Antibody

Acetyl-CoA carboxylase alpha (ACCα or ACACA) is a crucial enzyme in fatty acid biosynthesis. This enzyme catalyzes the conversion of acetyl-CoA to malonyl-CoA, a key step in the production of fatty acids. This enzyme plays a vital role in various cellular functions, including energy storage, membrane formation, and hormone production. The activity of Acetyl-CoA carboxylase alpha is tightly regulated by factors such as insulin, glucagon, and dietary fat intake, ensuring a balance between fatty acid synthesis and catalysis. Phosphorylation at serine 79 (Ser79) is a critical regulatory mechanism in response to changes in energy status and nutrient availability. This specific phosphorylation event inhibits the enzyme activity, thereby reducing the production of malonyl-CoA, a key precursor in fatty acid synthesis. Dysregulation of Acetyl-CoA carboxylase alpha is associated with several metabolic disorders, including obesity, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and certain cancers. Hence, targeting Acetyl-CoA carboxylase alpha can help reduce lipid accumulation and alleviate mitochondrial dysfunction, making it a potential therapeutic target for these conditions.