Biolegend, 682604, Alexa Fluor® 594 anti-TOX Antibody

TOX is a member of the high-mobility group (HMG) box superfamily of DNA-binding proteins and is originally identified as the thymic transcript expressed in CD4 + CD8 + double positive T-cells. TOX is also defined as part of a small subfamily of transcription factors consisting of TOX2, TOX3, and TOX4, which share conserved HMG-box sequences. TOX is highly upregulated in thymocytes undergoing positive selection and is required for the differentiation and development of various T-cell subsets, such as CD4 + T cells, regulatory T cells, and natural killer T cells (NKTs). TOX-deficient mice fail to develop lymph nodes and have significantly diminished numbers of CD4+ T-cells, NK cells, and ILC cells.