Biolegend, 685203, Alexa Fluor® 594 anti-HDAC3 Antibody
25microg
Catalog Number: 685203
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| Verified Reactivity | Human, Mouse |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Human HDAC3 recombinant protein (405-424 a.a.) conjugated to KLH. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | ICC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 1.25 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Application Notes |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing). |
| RRID | AB_2617024 (BioLegend Cat. No. 685203) |
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| Structure | 428 amino acids with a predicted molecular weight of 49 kD. It belongs to the class I histone deacetylase family. |
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| Distribution | Nucleus. |
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| Function | HDAC3 is a deacetylase responsible for the deacetylation of lysine resides on core histones and other non-histone proteins. |
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| Interaction | Forms heterodimer with YY1. Interacts with HDAC7, 9, 10, DACH1, DAXX, BCOR, MJD2A/JHDM3A, NRIP1, PRDM6, and SRY. |
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| Biology Area | Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors |
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| Antigen References | 1. Hua G, et al. 2016. Proc Natl Acad Sci USA. 113:E626. 2. Choi HK, et al. 2015. Nat. Commun. 6:8225. 3. Kim WY, et al. 2015. Int. J. Mol. Med. 35(1):202-10. 4. McHugh CA, et al. 2015. Nature 521:232. 5. Sun Z, et al. 2013. Mol. Cell. 52:769. 6. Sun Z, et al. 2012. Nat. Med. 18:934. |
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| Gene ID | 8841 |
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| UniProt | View information about HDAC3 on UniProt.org |
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| Clone | W15097A |
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| Regulatory Status | RUO |
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| Other Names | Histone deacetylase 3, HD3, SMAP45, RPD3-2 |
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| Isotype | Mouse IgG2b, κ |
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