Biolegend, 697207, Alexa Fluor® 488 anti-Cytokeratin 17 Antibody
25microg
Catalog Number: 697207
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Human Cytokeratin 17 peptide (415-432 a.a.) conjugated to KLH |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | 0.5 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | ICC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.5 - 2.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Blue Laser (488 nm) |
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| Application Notes |
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| This clone does not cross-react with mouse (in-house tested).As per the Human Protein Atlas RNA level dataset, A549 cell is expected to have a low level of Cytokeratin 17 expression. |
| RRID | AB_2820116 (BioLegend Cat. No. 697207) AB_2820117 (BioLegend Cat. No. 697208) |
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| Structure | 432 amino acids with a predicted molecular weight of 48 kD. Belongs to the type-I intermediate filament family. |
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| Distribution | Cytoplasm |
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| Function | Cytokeratin 17 is a type I intermediate filament protein and is involved in promoting cell growth, chemokine production, and tumorigenesis. |
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| Interaction | Forms a heterodimer with a type I or a type II keratin. Interacts with TRADD and SFN. |
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| Biology Area | Cancer Biomarkers, Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | Intermediate Filaments |
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| Antigen References | 1. Hobbs RP, et al. 2016. Oncogene. 35:5653. 2. Escobar-Hoyos LF, et al. 2015. Cancer Res. 75:3650. 3. Chung BM, et al. 2015. J. Cell. Biol. 208:613. 4. Sankar S, et al. 2013. Mol. Cell. Biol. 33:4448. 5. Jin L, et al. 2014. Med. Res. Rev. 34:438. 6. Depianto D, et al. 2010. Nat. Genet. 42:910. |
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| Gene ID | 3872 |
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| UniProt | View information about Cytokeratin 17 on UniProt.org |
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| Clone | W16131A |
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| Regulatory Status | RUO |
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| Other Names | Keratin, type I cytoskeletal 17, keratin-17 (K-17), cytokeratin-17 (CK-17), KRT17, CK17, K17 |
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| Isotype | Rat IgG2b, κ |
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