Biolegend, 740502, LEGENDplex™ Human Macrophage/Microglia Panel (13-plex) with Filter Plate

Macrophages are derived from the differentiation of monocytes in response to an infection or tissue damage. Their primary function is to recognize, engulf, and destroy pathogens, dying or dead cells and cellular debris. Macrophages are also professional antigen presenting cells that play a crucial role in modulating the host response, secreting an array of cytokines which aid in host defense, tissue repair, and immunoregulation. The LEGENDplex™ Human Macrophage/Microglia Panel (13-plex) is a bead-based multiplex assay panel, which uses fluorescence-encoded beads suitable for use on various flow cytometers. It allows for simultaneous quantification 13 key targets involved in monocyte differentiation and macrophage function including IL-12p70, TNF-α, IL-6, IL-4, IL-10, IL-1β, Arginase, TARC, IL-1RA, IL-12p40, IL-23, IFN-γ, and IP-10. This assay panel provides higher detection sensitivity and broader dynamic range than traditional ELISA methods. The panel has been validated for use on cell culture supernatant, serum, and plasma samples. The LEGENDplex™ Human Macrophage/Microglia Panel is designed to allow flexible customization within the panel. It can also be divided into sub-panels such as: LEGENDplex™ Human M1 Macrophage Panel (8-plex) LEGENDplex™ Human M2 Macrophage Panel (6-plex) LEGENDplex™ Human M1/M2 Macrophage Panel (10-plex) Please visit www.biolegend.com/legendplex for more information on how to mix and match within the panel.